| Title | Burkholderia cepacia Complex Infection in a Cohort of Italian Patients with Cystic Fibrosis |
|---|---|
| Author | Antonietta Lambiase1*, Valeria Raia2, Stefania Stefani3, Angela Sepe2, Pasqualina Ferri2, Paolo Buonpensiero2, Fabio Rossano1, and Mariassunta Del Pezzo1 |
| Address | 1Department of Biology and Pathology Cellular and Molecular “Luigi Califano”, 2Department of Pediatrics, Regional Cystic Fibrosis Center, University of Naples “Federico II”, Pansini Street 5-80131, Italy, 3Department of Microbiological and Gynecological Sciences, University of Catania, Italy |
| Bibliography | Journal of Microbiology, 45(3),275-279, 2007, |
| DOI | |
| Key Words | cystic fibrosis, Burkholderia cepacia complex, rec-A gene, PFGE |
| Abstract | The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01). |
| Download PDF | 45(3)-15.pdf |