| Title | Minireivew] Protective Role of Gut Commensal Microbes against Intestinal Infections |
|---|---|
| Author | My Young Yoon1,2, Keehoon Lee1,3, and Sang Sun Yoon1,2,3* |
| Address | 1Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea, 2Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea, 3Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea |
| Bibliography | Journal of Microbiology, 52(12),983-989, 2014, |
| DOI | 10.1007/s12275-014-4655-2 |
| Key Words | gut microbiota, enteropathogenic bacterial infection, colonization resistance |
| Abstract | The human gastrointestinal tract is colonized by multitudes of microorganisms that exert beneficial effects on human health. Mounting evidence suggests that intestinal microbiota contributes to host resistance against enteropathogenic bacterial infection. However, molecular details that account for such an important role has just begun to be understood. The commensal microbes in the intestine regulate gut homeostasis through activating the development of host innate immunity and producing molecules with antimicrobial activities that directly inhibit propagation of pathogenic bacteria. Understanding the protective roles of gut microbiota will provide a better insight into the molecular basis that underlies complicated interaction among host-pathogen-symbiont. In this review, we highlighted recent findings that help us broaden our knowledge of the intestinal ecosystem and thereby come up with a better strategy for combating enteropathogenic infection. |