| Title | The Gut Microbiota Mediates the Protective Effects of Spironolactone on Myocardial Infarction |
|---|---|
| Author | Lu Li1,2†, Jian‑Yong Sun1,2†, Yu‑Lin Li1,2, Shi‑Wei Zhu3, and Sheng‑Zhong Duan1,2* |
| Address | 1Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, People’s Republic of China, 2Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai 200011, People’s Republic of China, 3Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, People’s Republic of China |
| Bibliography | Journal of Microbiology, 62(10),883–895, 2024, |
| DOI | 10.1007/s12275-024-00164-7 |
| Key Words | Myocardial infarction · Spironolactone · Antibiotic · Gut microbiota · Lactobacillus vaginalis |
| Abstract | Myocardial infarction (MI) is a type of cardiovascular disease that influences millions of human beings worldwide and has a great rate of mortality and morbidity. Spironolactone has been used as a critical drug for the treatment of cardiac failure and it ameliorates cardiac dysfunction post-MI. Despite these findings, whether there is a relationship between the therapeutic effects of spironolactone and the gut microorganism after MI has not been determined. In our research, we used male C57BL/6 J mice to explore whether the gut microbiota mediates the beneficial function of spironolactone after myocardial infarction. We demonstrated that deletion of the gut microbiota eliminated the beneficial function of spironolactone in MI mice, displaying exacerbated cardiac dysfunction, cardiac infarct size. In addition, the gut microbiota was altered by spironolactone after sham or MI operation in mice. We also used male C57BL/6 J mice to investigate the function of a probiotic in the myocardial infarction. In summary, our findings reveal a precious role of the gut flora in the therapeutic function of spironolactone on MI. |