Title Human Antibody Responses to Capsular Polysaccharides of Streptococcus pneumoniae 6B, 14, and 19F
Author Kim, Ji Hye · Kim, Kyung Hyo¹ · Kim, Jung Soo² · Song, Jae Ho² · Park, Moon Kook *
Address Faculty of Biological Sciences; ¹Department of Pediatrics, College of Medicine Ehwa Women's university; ²Department of Pediatrics, Chonbuk National University
Bibliography Journal of Microbiology, 36(4),303-307, 1998,
Key Words Antibody, isotype, Streptococcus pneumoniae
Abstract Human antibody responses to Streptococcus pneumoniae 6B, 14, and 19F capsular polysaccharide were analyzed. Thirty-one healthy young adults were immunized with the pneumococcal 23-valent PS vaccine. serum samples were obtained from them before and 1 month after vaccination. The amounts of total antibody, heavy chain and light chain isotypes were determined by enzyme-linked immunosorbent assay (ELISA). Vaccination increased the total lebvels of anti6B, anti-14, and anti-19F PS antibodies by 3.4-fold, 3.8-fold and 4.1-fold, respectively. Some inantibody was predominant in the responses to the three PSs, and most of the IgG anti-PS antibodies were IgG2 isotype. There was no significant difference in the k and λresponses.
Download PDF Eng_360412_303-307p.pdf