| Title | Cytokine-Inducing and T Cell Mitogenic Effects of Cordyceps hepialidicola |
|---|---|
| Author | Jong-Soon Lim 1,3 , Seung-Hyung Kim 1,3 , Jeong-Youl Choi 2,3 , Jin-Seo Park 2,3 , Seong Joo Park 2,3 , and Kwang-Soo Shin 2,3 * |
| Address | 1 College of Oriental Medicine, 2 Department of Microbiology, College of Sciences, and 3 Institute of Traditional Medicine and Bioscience, Daejeon Uni |
| Bibliography | Journal of Microbiology, 39(3),181-185, 2001, |
| DOI | |
| Key Words | Cordyceps hepialidicola, taxonomy, cytokines, T lymphocytes |
| Abstract | The morphological characteristics of newly isolated Cordyceps hepialidicola were characterized, and the phylogenetic relationships with other Cordyceps species were investigated using a sequence analysis of the internal transcribed spacer (ITS). The PCR product of 592 bp showed a homology of 92 and 91% with C. militaris and C. nutans, respectively. In an in vitro model using mouse peripheral blood mononuclear cells (PBMC), a methanol extract of C. hepialidicola induced multiple cytokines, including IFN-[gamma], IL-4, and IL-18. The extract also enhanced the percentages of the CD4^+ and CD8^+ T cells in the healthy murine PBMCs to 56.1% and 13.0%, respectively. The percentages of CD4^+ and CD8^+ in the untreated controls were 28.4 and 7.3%, and concanavalin A-treated positive controls were 62.4 and 18.3%, respectively. |
| Download PDF | 393-17.pdf |