Title Characterization and Cytotoxic Activities of Nonadecanoic Acid Produced by Streptomyces scabiei subsp. chosunensis M0137 (KCTC 9927)
Author Jin-Cheol Yoo 1 , Ji-Man Han 1 , Seung-Kwan Nam 1 , Ok-Hyun Ko 1 , Cheol-Hee Choi 2 , Keun-Hong Kee 3 , Jae-Kyung Sohng 4 , Jung-Sun Jo and Chi-Nam Seong *
Address Department of Biological Science, Sunchon National University, Sunchon 540-742, Korea; 1 Department of Pharmacy, 2 Department of Pharmacology and 3 Department of Pathology, Chosun University, Gwangju 501-759, Korea; 4 Department of Chemistry, Sunmoon University, Asan 337-840, Korea
Bibliography Journal of Microbiology, 40(4),331-334, 2002,
Key Words Streptomyces scabiei subsp. chosunensis M0137, nonadecanoic acid, anti-tumor activity, inhibitor of IL-12 production
Abstract The substance 0116p, which exhibits cytotoxicity against human macrophage cell line THP-1, was isolated from a mycelial extract of Streptomyces scabiei subsp. chosunensis M0137. The cytotoxic substance was purified by Diaion-HP20 adsorption, solvent extraction, Sephadex LH-20 column chromatography, and silica-gel column chromatography. The molecular formula is C_19 H_38 O_2 (MW 301.10) based on elemental and spectrometric analysis. It was identified as nonadecanoic acid by NMR spectral data. It exhibits cytotoxic activities in various human cancer cell lines, including A549, SK-OV-3, SK-MEL-2 and HCT-15. In addition, 0116p also inhibits IL-12 production in lipopolysaccharide-activated macrophages.
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