| Title | Regulation of Class II Bacteriocin Production by Cell-Cell Signaling |
|---|---|
| Author | Luis E. N. Quadri |
| Address | Weill Medical College of Cornell University, Department of Microbiology and Immunology, 1300 York Avenue, New York, NY 10021, USA (Received May 2, 2003) |
| Bibliography | Journal of Microbiology, 41(3),175-182, 2003, |
| DOI | |
| Key Words | quorum sensing, antimicrobial peptide, signal transduction, gene regulation |
| Abstract | Production of ribosomally synthesized antimicrobial peptides usually referred to as bacteriocins is an inducible trait in several gram positive bacteria, particularly in those belonging to the group of lactic acid bacteria. In many of these organisms, production of bacteriocins is inducible and induction requires secretion and extracellular accumulation of peptides that act as chemical messengers and trigger bacteriocin production. These inducer peptides are often referred to as autoinducers and are believed to permit a quorum sensing-based regulation of bacteriocin production. Notably, the peptides acting as autoinducers are dedicated peptides with or without antimicrobial activity or the bacteriocins themselves. The autoinducer-dependent induction of bacteriocin production requires histidine protein kinases and response regulator proteins of two-component signal transduction systems. The current working model for the regulation of class II bacteriocin production in lactic acid bacteria and the most relevant direct and indirect pieces of evidence supporting the model are discussed in this minireview. |
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