Title Strategies Against Human Papillomavirus Infection and Cervical Cancer
Author Woon-Won Jung1, Taehoon Chun2, Donggeun Sul3, Kwang Woo Hwang4, Hyung-Sik Kang5, Duck Joo Lee6, and In-Kwon Han1,7,*
Address 1MyGene Bioscience Institute, Sungok Bldg. 5th floor, 202-16, Nonhyun Dong, Kangnam Ku, Seoul 405-847, Republic of Korea, 2Department of Microbiology and Immunology, School of Medicine, Hanyang University,Haeng-Dang Dong, Sung-Dong Ku, Seoul 133-791, Republic of Korea, 3Environmental Toxico-Genomic and Proteomic Center, College of Medicine, Korea University, 5 Anam Dong, Sungbuk Ku, Seoul 136-701, Republic of Korea, 4Department of Immunology, College of Pharmacy, Chung-Ang University, 221 HukSuk Dong, Dong-Jak Ku, Seoul 156-756, Republic of Korea, 5School of Biological Sciences and Technology, Biotechnology Research Institute, Chonnam University, 300 Yongbong Dong, Buk Ku, Kwangju 500-757, Republic of Korea, 6Department of Family Medicine, Samsung Cheil Hospital, Sungkyunkwan University,1-18 Mookjung Dong, Joong Ku, Seoul 100-380, Republic of Korea, 7Department of Internal Medicine, Samsung Cheil Hospital, Sungkyunkwan University, 1-18 Mookjung Dong, Joong Ku, Seoul 100-380, Republic of Korea
Bibliography Journal of Microbiology, 42(4),255-266, 2004,
Key Words cervical cancer, human papillomavirus, risk group, therapy, vaccine
Abstract Papillomaviruses infect a wide variety of animals, including humans. The human papillomavirus (HPV), in particular, is one of the most common causes of sexually transmitted disease. More than 200 types of HPV have been identified by DNA sequence data, and 85 HPV genotypes have been well characterized to date. HPV can infect the basal epithelial cells of the skin or inner tissue linings, and are, accordingly, categorized as either cutaneous or mucosal type. HPV is associated with a panoply of clinical conditions, ranging from innocuous lesions to cervical cancer. In the early 1980s, studies first reported a link between cervical cancer and genital HPV infection. Genital HPV infections are now recognized to be a major risk factor in at least 95% of cervical cancers. 30 different HPV genotypes have been identified as causative of sexually transmitted diseases, most of which induce lesions in the cervix, vagina, vulva, penis, and anus, as the result of sexual contact. There is also direct evidence demonstrating that at least four of these genotypes are prerequisite factors in cervical cancer. The main aim of this review was to evaluate the current literature regarding the pathovirology, diagnostics, vaccines, therapy, risk groups, and further therapeutic directions for HPV infections. In addition, we reviewed the current status of HPV infections in South Korean women, as evidenced by our data.
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