| Title | Conserved Virulence Factors of Pseudomonas aeruginosa are Required for Killing Bacillus subtilis |
|---|---|
| Author | Shin-Young Park1, Yun-Jeong Heo1, Young-Seok Choi1, Eric Deziel2, and You-Hee Cho1,* |
| Address | 1Department of Life Science, Sogang University, Seoul 121-742, Republic of Korea, 2INRS-Institut Armand-Frappier, Laval, Quebec H7V 1B7, Canada |
| Bibliography | Journal of Microbiology, 43(5),443-450, 2005, |
| DOI | |
| Key Words | Bacillus, Pseudomonas aeruginosa, survival, virulence |
| Abstract | The multi-host pathogen, Pseudomonas aeruginosa, possesses an extraordinary versatility which makes it capable of surviving the adverse conditions provided by environmental, host, and, presumably, competing microbial factors in its natural habitats. Here, we investigated the P. aeruginosa-Bacillus subtilis interaction in laboratory conditions and found that some P. aeruginosa strains can outcompete B. subtilis in mixed planktonic cultures. This is accompanied by the loss of B. subtilis viability. The bactericidal activity of P. aeruginosa is measured on B. subtilis plate cultures. The bactericidal activity is attenuated in pqsA, mvfR, lasR, pilB, gacA, dsbA, rpoS, and phnAB mutants. These results suggest that P. aeruginosa utilizes a subset of conserved virulence pathways in order to survive the conditions provided by its bacterial neighbors. |
| Download PDF | 443-450.pdf |