| Title | Production and Biological Activity of Laidlomycin, Anti-MRSA/VRE Antibiotic from Streptomyces sp. CS684 |
|---|---|
| Author | Jin Cheol Yoo1, Jun Ho Kim1, Jung Wan Ha1, Nae Soo Park1, Jae Kyung Sohng2, June Woo Lee3, Seong Chan Park4, Mi Sun Kim4, and Chi Nam Seong4* |
| Address | 1Department of Pharmacy, Chosun University, Gwangju 501-759, Republic of Korea, 2Department of Pharmaceutical Engineering, Sunmoon University, Chungnam 337-708, Republic of Korea, 3Department of Environmental Engineering, College of Applied Science, Catholic University of Pusan, Pusan 607-757, Republic of Korea, 4Department of Biology, College of Natural Sciences, Sunchon National University, Jeonnam 540-742, Republic of Korea |
| Bibliography | Journal of Microbiology, 45(1),6-10, 2007, |
| DOI | |
| Key Words | Anti-MRSA, Anti-VRE, polyether antibiotic, laidlomycin, Streptomyces sp. CS684 |
| Abstract | Culture broth of a streptomycete isolate, Streptomyces sp. CS684 showed antibacterial activity on methicilin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE). Among purified substances from the organism, CSU-1, which is active against MRSA and VRE, is a C37H62O12Na (M+, 721.3875), and identified as laidlomycin. The anti-MRSA and anti-VRE activity of CSU-1 was stronger than oxacillin and vancomycin. Phylogenetic analysis showed that strain CS684 is very similar to Streptomyces ardus NRRL 2817T, whereas the ability of Streptomyces sp. CS684 to produce laidlomycin was shown to be unique. |
| Download PDF | JM45(1)-02.pdf |