Title REVIEW] The Linkage between Reverse Gyrase and Hyperthermophiles: A Review of Their Invariable Association
Author Michelle Heine and Sathees B.C. Chandra*
Address Department of Biological, Chemical and Physical Sciences, Roosevelt University, Chicago, IL-60605, USA
Bibliography Journal of Microbiology, 47(3),229-234, 2009,
Key Words thermophiles, hyperthermophiles, reverse gyrase, positive supercoiling, negative supercoiling, type I topoisomerase, helicase
Abstract With the discovery of reverse gyrase in 1972, from Yellowstone National Park, isolated from Sulfolobus acidocaldarius, it has been speculated as to why reverse gyrase can be found in all hyperthermophiles and just what exactly its role is in hyperthermophilic organisms. Hyperthermophiles have been defined as organisms with an optimal growth temperature of above 85°C. Reverse gyrase is responsible for the introduction of positive supercoils into closed circular DNA. This review of reverse gyrase in hyperthermophilic microorganisms summarizes the last two decades of research performed on hyperthermophiles and reverse gyrase in an effort to provide an up to date synopsis of their invariable association. From the data gathered for this review it is reasonable to hypothesize that reverse gyrase is closely tied to hyperthermophilic life.