Title NOTE] Nomenclature of ISCR1 Elements Capable of Mobilizing Antibiotic Resistance Genes Present in Complex Class 1 Integrons
Author Seung Ghyu Sohn1, Jae Jin Lee1, Jae Seok Song1, Jung Hun Lee1,2, Ha Ik Sun1, Kwang Seung Park1, Il Kwon Bae3, Jung-Hyun Lee2, Byeong Chul Jeong1, and Sang Hee Lee1*
Address 1Drug Resistance Proteomics Laboratory, Department of Biological Sciences, Myongji University, Gyeonggido 449-728, Republic of Korea, 2Marine Biotechnology Research Center, Korea Ocean Research and Development Institute, Ansan 425-600, Republic of Korea, 3Research Institute for Antimicrobial Resistance, Kosin University College of Medicine, Busan 602-030, Republic of Korea
Bibliography Journal of Microbiology, 47(4),514-516, 2009,
Key Words nomenclature, ISCR1, complex class 1 integron
Abstract The dissemination of many antibiotic resistance genes has arisen among members of the family Enterobacteriaceae. The dissemination mechanism of these antibiotic resistance genes is closely linked with insertion sequence common region 1 (ISCR1). Thus, caution must be taken in clinical settings to prevent further dissemination of these antibiotic resistance genes. A nomenclature system of ISCR1 variants, important for the antibiotic resistance dissemination, was proposed. The proposed system can designate all ISCR1 variants on the basis of the detection time and by considering amino-acid substitution(s) compared with ISCR1a. This nomenclature system of ISCR1 variants can be applied to 19 groups (ISCR1 to ISCR19) of the ISCR family and help some researchers to correctly designate new ISCR subgroups.