Title |
Evidence That Vibrio vulnificus AhpC2 Is Essential for Survival Under High Salinity by Modulating Intracellular Level of ROS |
Author |
Myung Jin Koh1, Hyun Sung Lee1, Jee Eun Rhee2, and Sang Ho Choi1* |
Address |
1National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Center for Agricultural Biomaterials, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Republic of Korea, 2Division of AIDS, Center for Immunology and Pathology, Korea National Institute of Health, Seoul 122-701, Republic of Korea |
Bibliography |
Journal of Microbiology, 48(1),129-133, 2010,
|
DOI |
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Key Words |
V. vulnificus ahpC2, salt stress, ROS |
Abstract |
Expression of ahpC2 encoding an alkyl hydroperoxide reductase of Vibrio vulnificus, a foodborne pathogen, was incrementally induced depending on NaCl concentrations in the culture. Growth of the ahpC2 mutant was significantly impaired with longer lag phase and lower growth rate when cultured under high salinity.
ROS was accumulated in V. vulnificus cells when stressed by exposure to high salinity, and the ahpC2 mutant accumulated higher level of ROS as compared with the parental wild type. Consequently, the combined results suggest that AhpC2 contributes to the growth of V. vulnificus under high salinity by scavenging ROS
in cells. |