Title Anti-HIV-1 Efficacy of Extracts from Medicinal Plants
Author Su-A Lee1, Seong-Karp Hong1, Chang-Il Suh1, Mi-Hwa Oh1, Jeong-Ho Park2, Byoung-Wook Choi2, Seung-Won Park1, and Soon-Young Paik1*
Address 1Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea, 2Department of Applied Chemistry and Biotechnology, Hanbat National University, Daejeon 305-719, Republic of Korea
Bibliography Journal of Microbiology, 48(2),249-252, 2010,
Key Words Anti-HIV-1, aqueous extracts, folk medicine, medicinal plants, organic extracts
Abstract The anti-HIV-1 activities of butanol, hexane, chloroform and water extracts from four widely used folk medicinal plants (Sophora flavescens, Tulipa edulis, Herba ephedra, and Pachyma hoelen Rumph) were evaluated in this study. The hexane extract of Pachyma hoelen Rumph, PH-4, showed effective inhibition against HIV-1. The 50% effective concentration (EC50) of PH-4 was 37.3 μg/ml in the p24 antigen assay and 36.8% in the HIV-1 recombinant RT activity test (at 200 μg/ml). In addition, the PH-4 showed the protective effect on the infected MT-4 cells, with a 58.2% rate of protection. The 50% cytotoxic concentration (CC50) of PH-4 was 100.6 μg/ml. These results suggest that PH-4 from Pachyma hoelen Rumph might be the candidate for the chemotherapy agent against HIV-1 infection with further study.