| Title |
Inhibitory Effect of Lactobacillus reuteri on Periodontopathic and Cariogenic Bacteria |
| Author |
Mi-Sun Kang1, Jong-Suk Oh1, Hyun-Chul Lee1, Hoi-Soon Lim2, Seok-Woo Lee3,4, Kyu-Ho Yang2,5, Nam-Ki Choi2,6, and Seon-Mi Kim2,6* |
| Address |
1Department of Microbiology, School of Medicine, Chonnam National University, Gwangju 501-746, Republic of Korea, 2Dental Science Research Institute, Chonnam National University, Gwangju 500-757, Republic of Korea, 3Department of Periodontics, Chonnam National University, Gwangju 500-757, Republic of Korea, 4Division of Periodontics, School of Dentistry, Marquette University, Milwaukee, WI, USA, 5Department of Pediatric Dentistry, Chonnam National University, Gwangju 500-757, Republic of Korea, 6Department of Pediatric Dentistry, Chonnam National University, Gwangju 500-757, Republic of Korea |
| Bibliography |
Journal of Microbiology, 49(2),193-199, 2011,
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| DOI |
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| Key Words |
Lactobacillus reuteri, periodontopathic bacteria, Streptococcus mutans, inhibitory effect, biofilms |
| Abstract |
The interaction between Lactobacillus reuteri, a probiotic bacterium, and oral pathogenic bacteria have not been studied adequately. This study examined the effects of L. reuteri on the proliferation of periodontopathic bacteria including Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, and Tannerella forsythia, and on the formation of Streptococcus mutans biofilms. Human-derived L. reuteri strains (KCTC 3594 and KCTC 3678) and rat-derived L. reuteri KCTC 3679 were used. All strains exhibited significant inhibitory effects on the growth of periodontopathic bacteria and the formation of S. mutans
biofilms. These antibacterial activities of L. reuteri were attributed to the production of organic acids, hydrogen peroxide, and a bacteriocin-like compound. Reuterin, an antimicrobial factor, was produced only by L. reuteri KCTC 3594. In addition, L. reuteri inhibited the production of methyl mercaptan by F. nucleatum and P. gingivalis. Overall, these results suggest that L. reuteri may be useful as a probiotic agent for improving oral health. |
