| Title |
NOTE] IL-10 Suppresses Bactericidal Response of Macrophages against Salmonella Typhimurium |
| Author |
Kyoung-Sun Lee1, Eui-Suk Jeong1, Seung-Ho Heo1,2, Jin-Hee Seo1, Dong-Gu Jeong1, and Yang-Kyu Choi1* |
| Address |
1Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea, 2Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea |
| Bibliography |
Journal of Microbiology, 49(6),1050-1053, 2011,
|
| DOI |
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| Key Words |
IL-10, macrophage, Salmonella |
| Abstract |
We report, herein, an attempt to determine whether an IL-10-induced immunological state affects the response of macrophages against Salmonella Typhimurium (ST). Pretreatment with mrIL-10 induced the intracellular invasion of ST into macrophages in a dose-dependent manner. It also activated AKT phosphorylation, cyclin D1, Bcl-XL, and COX-2 upon ST infection, which may correlate with Salmonella’s survival within the macrophages. However, I-κB phosphorylation was shown to be inhibited, along with the expression of TNF-α and MIP-2α mRNA. Therefore, IL-10 not only suppresses the bactericidal response of macrophages against ST, but also ultimately causes infected macrophages to function as hosts for ST replication. |
