| Title |
REVIEW] Cell Migration: Regulation of Cytoskeleton by Rap1 in Dictyostelium discoideum |
| Author |
Mi-Rae Lee and Taeck J. Jeon* |
| Address |
Department of Biology, College of Natural Sciences, Chosun University, Gwangju 501-759, Republic of Korea |
| Bibliography |
Journal of Microbiology, 50(4),555-561, 2012,
|
| DOI |
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| Key Words |
cell migration, Dictyostelium, chemotaxis, Rap1, cytoskeleton |
| Abstract |
Cell movement involves a coordinated regulation of the cytoskeleton, F-actin-mediated protrusions at the front and myosin-mediated contraction of the posterior of a cell. The small GTPase Rap1 functions as a key regulator in the spatial and temporal control of cytoskeleton reorganization for cell migration. This review outlines the establishment of cell polarity by differential localizations of the cytoskeleton and discusses the spatial and temporal regulation of cytoskeleton
reorganization via the Rap1 signaling pathway during chemotaxis with a focus on recent advances in the study of chemotaxis using a simple eukaryotic model organism, Dictyostelium discoideum. |
