| Title |
NOTE] Susceptibility of Human H3N2 Influenza Virus to Oseltamivir in South Korea, 2009–2011 |
| Author |
Sehee Park1,2, Jin Il Kim1,2, Ilseob Lee1,2, Sangmoo Lee1,2, Min-Woong Hwang1,2, Joon-Yong Bae1,2, Jun Heo1,2, Eun-Joo Lim3, Won-Seok Seok3, Hee Jin Cheong4, Joon Young Song4, Woo Joo Kim4, and Man-Seong Park1,2* |
| Address |
1Department of Microbiology, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea, 2Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea, 3Infectious Disease Investigation Division, Gangwon Institute of Health and Environment, Chuncheon 200-820, Republic of Korea, 4Division of Infectious Diseases, Korea University Guro Hospital, College of Medicine, Korea University, Seoul 152-703, Republic of Korea |
| Bibliography |
Journal of Microbiology, 50(6),1067-1070, 2012,
|
| DOI |
|
| Key Words |
influenza, neuraminidase, oseltamivir |
| Abstract |
During the 2009–2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays. |
