| Title | MINIREVIEW] Regulation of Escherichia coli RNase III activity |
|---|---|
| Author | Boram Lim1, Minji Sim1, Howoon Lee1, Seogang Hyun1, Younghoon Lee2, Yoonsoo Hahn1, Eunkyoung Shin3*, and Kangseok Lee1* |
| Address | 1Department of Life Science, Chung-Ang University, Seoul 156-756, Republic of Korea, 2Department of Chemistry, KAIST, Daejeon 305-701, Republic of Korea, 3College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea |
| Bibliography | Journal of Microbiology, 53(8),487-494, 2015, |
| DOI | 10.1007/s12275-015-5323-x |
| Key Words | RNase III, mRNA stability, regulator, catalytic mechanism, stress response, osmotic stress |
| Abstract | Bacterial cells respond to changes in the environment by adjusting their physiological reactions. In cascades of cellular responses to stresses of various origins, rapid modulation of RNA function is known to be an effective biochemical adaptation. Among many factors affecting RNA function, RNase III, a member of the phylogenetically highly conserved endoribonuclease III family, plays a key role in posttranscriptional regulatory pathways in Escherichia coli. In this review, we provide an overview of the factors affecting RNase III activity in E. coli. |