Title MINIREVIEW] Regulation and function of the Salmonella MgtC virulence protein
Author Jang-Woo Lee and Eun-Jin Lee*
Address Department of Genetic Engineering and Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17035, Republic of Korea
Bibliography Journal of Microbiology, 53(10),667-672, 2015,
DOI 10.1007/s12275-015-5283-1
Key Words mgtC, Salmonella virulence, ATP homeostasis
Abstract Salmonella enterica serovar Typhimurium produces many virulence proteins to cause diseases. The Salmonella MgtC protein is one of such virulence proteins specially required for intracellular proliferation inside macrophages and mouse virulence. In this review, we will cover how the mgtC gene is turned on or off and what the signals required for mgtC expression are. Later in this review, we will discuss a recent understanding of MgtC function in Salmonella pathogenesis by identifying its target proteins.