Title |
MINIREVIEW] Histone deacetylase-mediated morphological transition in Candida albicans |
Author |
Jueun Kim, Ji-Eun Lee, and Jung-Shin Lee* |
Address |
Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea |
Bibliography |
Journal of Microbiology, 53(12),805-811, 2015,
|
DOI |
10.1007/s12275-015-5488-3
|
Key Words |
Candida albicans, morphological transition, histone
deacetylases (HDACs), transcription factor, chromatin
structure |
Abstract |
Candida albicans is the most common opportunistic fungal
pathogen, which switches its morphology from single-cell
yeast to filament through the various signaling pathways responding
to diverse environmental cues. Various transcriptional
factors such as Nrg1, Efg1, Brg1, Ssn6, and Tup1 are
the key components of these signaling pathways. Since C.
albicans can regulate its transcriptional gene expressions using
common eukaryotic regulatory systems, its morphological
transition by these signaling pathways could be linked
to the epigenetic regulation by chromatin structure modifiers.
Histone proteins, which are critical components of eukaryotic
chromatin structure, can regulate the eukaryotic chromatin
structure through their own modifications such as acetylation,
methylation, phosphorylation and ubiquitylation. Recent
studies revealed that various histone modifications, especially
histone acetylation and deacetylation, participate in morphological
transition of C. albicans collaborating with well-known
transcription factors in the signaling pathways. Here, we review
recent studies about chromatin-mediated morphological
transition of C. albicans focusing on the interaction between
transcription factors in the signaling pathways and histone
deacetylases. |