Title MINIREVIEW] Multidrug efflux pumps in Staphylococcus aureus and their clinical implications
Author Soojin Jang
Address Institut Pasteur Korea, Seongnam 13488, Republic of Korea
Bibliography Journal of Microbiology, 54(1),1-8, 2016,
DOI 10.1007/s12275-016-5159-z
Key Words multidrug efflux pumps, multidrug resistance, Staphylococcus aureus, MRSA
Abstract Antibiotic resistance is rapidly spreading among bacteria such as Staphylococcus aureus, an opportunistic bacterial pathogen that causes a variety of diseases in humans. For the last two decades, bacterial multidrug efflux pumps have drawn attention due to their potential association with clinical multidrug resistance. Numerous researchers have demonstrated efflux-mediated resistance in vitro and in vivo and found novel multidrug transporters using advanced genomic information about bacteria. This article aims to provide a concise summary of multidrug efflux pumps and their important clinical implications, focusing on recent findings concerning S. aureus efflux pumps.