| Title | Antibacterial metabolites from the Actinomycete Streptomyces sp. P294 |
|---|---|
| Author | Huining Su1, Hongwei Shao2, Keqin Zhang1, and Guohong Li1* |
| Address | 1Key Laboratory for Conservation and Utilization of Bio-resource, and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, 650091, Yunnan, P. R. China, 2Angang General Hospital, Anshan, 114021, P. R. China |
| Bibliography | Journal of Microbiology, 54(2),131-135, 2016, |
| DOI | 10.1007/s12275-016-5311-9 |
| Key Words | Streptomyces sp., new compounds, antibacterial activity, nematicidal activity |
| Abstract | The Actinomycete strain P294 was isolated from soil and identified as Streptomyces sp. based upon the results of 16S rRNA sequence analysis. Three compounds obtained from the solid fermentation products of this strain have been determined by 1D, 2D NMR and HRMS experiments. These compounds include two new compounds angumycinones C (1) and D (2), and the known compound X-14881 E (3). All compounds were assayed for antibacterial and nematicidal activity. The results showed the three compounds had different degrees of inhibitory activity against several target bacteria but no significant toxicity against the nematode Caenorhabditis elegans. |