Title |
Inhibitory effects of bee venom and its components against viruses in vitro and in vivo |
Author |
Md Bashir Uddin1,2, Byeong-Hoon Lee1, Chamilani Nikapitiya1, Jae-Hoon Kim1, Tae-Hwan Kim1, Hyun-Cheol Lee1, Choul Goo Kim3, Jong-Soo Lee1*, and Chul-Joong Kim1* |
Address |
1College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea, 2Faculty of Veterinary and Animal Science, Sylhet Agricultural University, Sylhet-3100, Bangladesh, 3Chung Jin Biotech Corporation, Ansan 15577, Republic of Korea |
Bibliography |
Journal of Microbiology, 54(12),853-866, 2016,
|
DOI |
10.1007/s12275-016-6376-1
|
Key Words |
anti-viral activity, bee venom, melittin, virucidal effect |
Abstract |
Bee venom (BV) from honey bee (Apis Melifera L.) contains
at least 18 pharmacologically active components including
melittin (MLT), phospholipase A2 (PLA2), and apamin etc.
BV is safe for human treatments dose dependently and proven
to possess different healing properties including antibacterial
and antiparasitidal properties. Nevertheless, antiviral
properties of BV have not well investigated. Hence, we
identified the potential antiviral properties of BV and its
component against a broad panel of viruses. Co-incubation
of non-cytotoxic amounts of BV and MLT, the main component
of BV, significantly inhibited the replication of enveloped
viruses such as Influenza A virus (PR8), Vesicular
Stomatitis Virus (VSV), Respiratory Syncytial Virus (RSV),
and Herpes Simplex Virus (HSV). Additionally, BV and MLT
also inhibited the replication of non-enveloped viruses such
as Enterovirus-71 (EV-71) and Coxsackie Virus (H3). Such
antiviral properties were mainly explained by virucidal mechanism.
Moreover, MLT protected mice which were challenged
with lethal doses of pathogenic influenza A H1N1
viruses. Therefore, these results provides the evidence that BV
and MLT could be a potential source as a promising antiviral
agent, especially to develop as a broad spectrum antiviral
agent. |