Title |
REVIEW] Modulation of the host immune response by respiratory syncytial virus proteins |
Author |
Megan E. Schmidt1 and Steven M. Varga1,2,3* |
Address |
1Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA, 2Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA, 3Department of Pathology, University of Iowa, Iowa City, IA 52242, USA |
Bibliography |
Journal of Microbiology, 55(3),161-171, 2017,
|
DOI |
10.1007/s12275-017-7045-8
|
Key Words |
RSV, virus, T cell, lung, vaccine |
Abstract |
Respiratory syncytial virus (RSV) causes severe respiratory
disease in both the very young and the elderly. Nearly all
individuals become infected in early childhood, and reinfections
with the virus are common throughout life. Despite its
clinical impact, there remains no licensed RSV vaccine. RSV
infection in the respiratory tract induces an inflammatory
response by the host to facilitate efficient clearance of the
virus. However, the host immune response also contributes
to the respiratory disease observed following an RSV infection.
RSV has evolved several mechanisms to evade the host
immune response and promote virus replication through
interactions between RSV proteins and immune components.
In contrast, some RSV proteins also play critical roles in activating,
rather than suppressing, host immunity. In this review,
we discuss the interactions between individual RSV proteins
and host factors that modulate the immune response
and the implications of these interactions for the course of
an RSV infection. |