| Title | An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication |
|---|---|
| Author | Seong Eun Jin1, Jung-Eun Kim1, Sun Yeou Kim2,3, Bang Ju Park4, and Yoon-Jae Song1* |
| Address | 1Department of Life Science, Gachon University, Seongnam 13120, Republic of Korea, 2College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea, 3Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea, 4Department of Electronic Engineering, Gachon University, Seongnam 13120, Republic of Korea |
| Bibliography | Journal of Microbiology, 55(12),984-988, 2017, |
| DOI | 10.1007/s12275-017-7477-1 |
| Key Words | hepatitis E virus, antiviral, Lysimachia mauritiana |
| Abstract | Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection. |