Title Antiviral activity of Poncirus trifoliata seed extract against oseltamivirresistant influenza virus
Author Yoonki Heo1, Yeondong Cho1, Kwon sung Ju1, Hansam Cho1, Ki Hoon Park1, Hanul Choi1, Jong Kwang Yoon1, Chiung Moon2, and Young Bong Kim3*
Address 1Department of Bio-industrial technologies, Konkuk University, Seoul 05029, Republic of Korea, 2Gueulri, Ansan 15588, Republic of Korea, 3Department of Bio-medical science and engineering, Konkuk University, Seoul 05029, Republic of Korea
Bibliography Journal of Microbiology, 56(8),586–592, 2018,
DOI 10.1007/s12275-018-8222-0
Key Words influenza, Poncirus trifoliata, antiviral agent, natural product
Abstract The emergence of oseltamivir-resistant variants of influenza virus has highlighted the necessity for the development of more effective novel antiviral drugs. To date, numerous researchers have focused on developing antiviral drugs using natural resources, such as traditional herbal medicines. Poncirus trifoliata is widely used in oriental medicine as a remedy for gastritis, dysentery, inflammation and digestive ulcers. In this study, we investigated the potential antiviral effect of the Poncirus trifoliata orange seed extract against influenza virus. An ethanol extract of Poncirus trifoliata seeds (PTex) inhibited the activity of influenza viruses, in particular, oseltamivir- resistant strains, in Madin-Darby canine kidney cells. In contrast to oseltamivir, PTex exerted a significant inhibitory effect on the cellular penetration pathway of the virus rather than HA receptor binding. The potent antiviral effect and novel working mechanism of PTex support its further development as an effective natural antiviral drug with a wide spectrum of activity against influenza and oseltamivir-resistant viruses.