Title |
[MINIREVIEW] Phylogenetic comparison of Epstein-Barr virus genomes |
Author |
Su Jin Choi1, Seok Won Jung1, Sora Huh1, Hyosun Cho2*, and Hyojeung Kang1* |
Address |
1College of Pharmacy, Research Institute of Pharmaceutical Sciences and Kyungpook National University Cancer Research Institute, Kyungpook National University, Daegu 41566, Republic of Korea, 2College of Pharmacy, Duksung Women’s University, Seoul 01369, Republic of Korea |
Bibliography |
Journal of Microbiology, 56(8),525–533, 2018,
|
DOI |
10.1007/s12275-018-8039-x
|
Key Words |
Epstein-Barr virus, phylogenetic analysis, genomic
variations |
Abstract |
Technologies used for genome analysis and whole genome
sequencing are useful for us to understand genomic characterization
and divergence. The Epstein-Barr virus (EBV)
is an oncogenic virus that causes diverse diseases such as
Burkitt’s lymphoma (BL), nasopharyngeal carcinoma (NPC),
Hodgkin’s lymphoma (HL), and gastric carcinoma (GC). EBV
genomes found in these diseases can be classified either by
phases of EBV latency (type-I, -II, and -III latency) or types
of EBNA2 sequence difference (type-I EBV, type-II EBV or
EBV-1, EBV-2). EBV from EBV-transformed lymphoblastoid
cell line (LCL) establishes type-III latency, EBV from NPC
establishes type-II latency, and EBV from GC establishes
type-I latency. However, other important factors play key
roles in classifying numerous EBV strains because EBV genomes
are highly diverse and not phylogenetically related
to types of EBV-associated diseases. Herein, we first reviewed
previous studies to describe molecular characteristics of EBV
genomes. Then, using comparative and phylogenetic analyses,
we phylogenetically analyzed molecular variations of EBV
genomes and proteins. The review of previous studies and
our phylogenetic analysis showed that EBV genomes and
proteins were highly diverse regardless of types of EBV-associated
diseases. Other factors should be considered in determining
EBV taxonomy. This review will be helpful to understand
complicated phylogenetic relationships of EBV genomes. |