Title |
REVIEW] Antibacterial strategies inspired by the oxidative stress and response networks |
Author |
So Youn Kim, Chanseop Park, Hye-Jeong Jang, Bi-o Kim, Hee-Won Bae, In-Young Chung, Eun Sook Kim, and You-Hee Cho* |
Address |
Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam 13488, Republic of Korea |
Bibliography |
Journal of Microbiology, 57(3),203–212, 2019,
|
DOI |
10.1007/s12275-019-8711-9
|
Key Words |
oxidative stress, stress response, OxyR, reactive
oxygen species (ROS), redox cycling, bactericidal, antibacterial |
Abstract |
Oxidative stress arises from an imbalance between the excessive
accumulation of reactive oxygen species (ROS) and
a cell’s capability to readily detoxify them. Although ROS are
spontaneously generated during the normal oxygen respiration
and metabolism, the ROS generation is usually augmented
by redox-cycling agents, membrane disrupters, and
bactericidal antibiotics, which contributes their antimicrobial
bioactivity. It is noted that all the bacteria deploy an arsenal
of inducible antioxidant defense systems to cope with the
devastating effect exerted by the oxidative stress: these systems
include the antioxidant effectors such as catalases and
the master regulators such as OxyR. The oxidative stress response
is not essential for normal growth, but critical to survive
the oxidative stress conditions that the bacterial pathogens
may encounter due to the host immune response and/or
the antibiotic treatment. Based on these, we here define the
ROS-inspired antibacterial strategies to enhance the oxidative
stress of ROS generation and/or to compromise the bacterial
response of ROS detoxification, by delineating the ROSgenerating
antimicrobials and the core concept of the bacterial
response against the oxidative stress. |