Title Intervention with kimchi microbial community ameliorates obesity by regulating gut microbiota
Author Seong-Eun Park1, Sun Jae Kwon2, Kwang-Moon Cho2, Seung-Ho Seo1, Eun-Ju Kim1, Tatsuya Unno3, So-Hyeon Bok4, Dae-Hun Park4*, and Hong-Seok Son1*
Address 1School of Korean Medicine, Dongshin University, Naju, 58245, Republic of Korea, 2AccuGene Inc., Incheon 22006, Republic of Korea, 3Faculty of Biotechnology, School of Life Sciences, SARI Jeju National University, Jeju 63243, Republic of Korea, 4Department of Nursing, Dongshin University, Naju, 58245, Republic of Korea
Bibliography Journal of Microbiology, 58(10),859–867, 2020,
DOI 10.1007/s12275-020-0266-2
Key Words obesity, kimchi microbial community, metabolomics, amplicon sequencing, microbiota
Abstract The objective of this study was to evaluate anti-obesity effects of kimchi microbial community (KMC) on obesity and gut microbiota using a high fat diet-induced mouse model compared to effects of a single strain. Administration of KMC decreased body weight, adipose tissue, and liver weight gains. Relative content of Muribaculaceae in the gut of the KMCtreated group was higher than that in the high-fat diet (HFD) group whereas relative contents of Akkermansiaceae, Coriobacteriaceae, and Erysipelotrichaceae were lower in KMCtreated group. Metabolic profile of blood was found to change differently according to the administration of KMC and a single strain of Lactobacillus plantarum. Serum metabolites significantly increased in the HFD group but decreased in the KMC-treated group included arachidic acid, stearic acid, fumaric acid, and glucose, suggesting that the administration of KMC could influence energy metabolism. The main genus in KMC was not detected in guts of mice in KMC-treated group. Since the use of KMC has advantages in terms of safety, it has potential to improve gut microbial community for obese people.