| Title | Trans-acting regulators of ribonuclease activity |
|---|---|
| Author | Jaejin Lee, Minho Lee*, and Kangseok Lee* |
| Address | Department of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea |
| Bibliography | Journal of Microbiology, 59(4),341–359, 2021, |
| DOI | 10.1007/s12275-021-0650-6 |
| Key Words | RNase regulator, RNase stability, post-translational regulation of RNase, trans-acting regulator, proteolysis |
| Abstract | RNA metabolism needs to be tightly regulated in response to changes in cellular physiology. Ribonucleases (RNases) play an essential role in almost all aspects of RNA metabolism, including processing, degradation, and recycling of RNA molecules. Thus, living systems have evolved to regulate RNase activity at multiple levels, including transcription, post-transcription, post-translation, and cellular localization. In addition, various trans-acting regulators of RNase activity have been discovered in recent years. This review focuses on the physiological roles and underlying mechanisms of trans-acting regulators of RNase activity. |