| Title | The comparison of microbial communities in thyroid tissues from thyroid carcinoma patients |
|---|---|
| Author | Chen-Jian Liu1†, Si-Qian Chen1†, Si-Yao Zhang1, Jia-Lun Wang1, Xiao-Dan Tang2,3, Kun-Xian Yang4,5*, and Xiao-Ran Li1* |
| Address | 1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, P. R. China, 2Gastroenterology Department, the First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, P. R. China, 3Gastroenterology Department, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, P. R. China, 4Oncology Department, the First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, P. R. China, 5Oncology Department, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, P. R. China |
| Bibliography | Journal of Microbiology, 59(11),988-1001, 2021, |
| DOI | 10.1007/s12275-021-1271-9 |
| Key Words | thyroid carcinoma, thyroid microbiota, cooccurrence network, Tax4Fun2, gut microbiota |
| Abstract | Thyroid carcinoma is a common endocrine organ cancer associated with abnormal hormone secretion, leading to the disorder of metabolism. The intestinal microbiota is vital to maintain digestive and immunologic homeostasis. The relevant information of the microbial community in the gut and thyroid, including composition, structure, and relationship, is unclear in thyroid carcinoma patients. A total of 93 samples from 25 patients were included in this study. The results showed that microbial communities existed in thyroid tissue; gut and thyroid had high abundance of facultative anaerobes from the Proteobacteria phyla. The microbial metabolism from the thyroid and gut may be affected by the thyroid carcinoma cells. The cooccurrence network showed that the margins of different thyroid tissues were unique areas with more competition; the stabilization of microcommunities from tissue and stool may be maintained by several clusters of species that may execute different vital metabolism processes dominantly that are attributed to the microenvironment of cancer. |