Title |
Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants |
Author |
Junsoo Park*, Rackhyun Park, Minsu Jang, Yea-In Park, and Yeonjeong Park |
Address |
Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea |
Bibliography |
Journal of Microbiology, 60(3),347-354, 2022,
|
DOI |
10.1007/s12275-022-1499-z
|
Key Words |
coronavirus, COVID-19, SARS-CoV-2, natural
compounds |
Abstract |
Coronavirus disease (COVID-19) can cause critical conditions
that require efficient therapeutics. Several medicines are derived
from plants, and researchers are seeking natural compounds
to ameliorate the symptoms of COVID-19. Viral enzymes
are popular targets of antiviral medicines; the genome
of coronaviruses encodes several enzymes, including RNAdependent
RNA polymerase and viral proteases. Various screening
systems have been developed to identify potential inhibitors.
In this review, we describe the natural compounds that
have been shown to exert inhibitory effects on coronavirus enzymes.
Although computer-aided molecular structural studies
have predicted several antiviral compound candidates, the current
review focuses on experimentally proven natural compounds. |