Title |
Nanoparticle and virus-like particle vaccine approaches against SARS-CoV-2 |
Author |
Chulwoo Kim1, Jae-Deog Kim2,3, and Sang-Uk Seo2,3* |
Address |
1Department of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul 02841, Republic of Korea, 2Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea, 3Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea |
Bibliography |
Journal of Microbiology, 60(3),335-346, 2022,
|
DOI |
10.1007/s12275-022-1608-z
|
Key Words |
nanoparticle, virus-like particle, SARS-CoV-2,
vaccine, COVID-19 |
Abstract |
The global spread of coronavirus disease 2019 caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection has provoked an urgent need for prophylactic measures.
Several innovative vaccine platforms have been introduced
and billions of vaccine doses have been administered
worldwide. To enable the creation of safer and more effective
vaccines, additional platforms are under development. These
include the use of nanoparticle (NP) and virus-like particle
(VLP) technology. NP vaccines utilize self-assembling scaffold
structures designed to load the entire spike protein or
receptor-binding domain of SARS-CoV-2 in a trimeric configuration.
In contrast, VLP vaccines are genetically modified
recombinant viruses that are considered safe, as they are
generally replication-defective. Furthermore, VLPs have indigenous
immunogenic potential due to their microbial origin.
Importantly, NP and VLP vaccines have shown stronger immunogenicity
with greater protection by mimicking the physicochemical
characteristics of SARS-CoV-2. The study of NPand
VLP-based coronavirus vaccines will help ensure the development
of rapid-response technology against SARS-CoV-2
variants and future coronavirus pandemics. |