| Title | Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins |
|---|---|
| Author | Na-Eun Kim and Yoon-Jae Song* |
| Address | Department of Life Science, Gachon University, Seongnam 13120, Republic of Korea |
| Bibliography | Journal of Microbiology, 60(3),300-307, 2022, |
| DOI | 10.1007/s12275-022-1502-8 |
| Key Words | inflammasome, interferon, severe acute respiratory syndrome corona virus 2 |
| Abstract | Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pathogenesis of SARS-CoV-2. While optimal IFN and inflammasome responses are essential for limiting SARS-CoV-2 infection, aberrant activation of these innate immune responses is associated with COVID-19 pathogenesis. In this review, we focus our discussion on recent findings on SARS-CoV-2-induced type I and III IFNs and NLRP3 inflammasome responses and the viral proteins regulating these mechanisms. |