| Title | SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways |
|---|---|
| Author | Soo-Jin Oh and Ok Sarah Shin* |
| Address | BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul 08308, Republic of Korea |
| Bibliography | Journal of Microbiology, 60(3),290-299, 2022, |
| DOI | 10.1007/s12275-022-1525-1 |
| Key Words | SARS-CoV-2, COVID-19, interferon, immunity |
| Abstract | With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies. |