| Title | T cell responses to SARS-CoV-2 in humans and animals |
|---|---|
| Author | Sameer-ul-Salam Mattoo and Jinjong Myoung* |
| Address | Korea Zoonosis Research Institute, Department of Bioactive Material Science and Genetic Engineering Research Institute, Jeonbuk National University, Jeonju 54531, Republic of Korea |
| Bibliography | Journal of Microbiology, 60(3),276-289, 2022, |
| DOI | 10.1007/s12275-022-1624-z |
| Key Words | SARS-CoV-2, T cell, coronavirus, immune response |
| Abstract | SARS-CoV-2, the causative agent of COVID-19, first emerged in 2019. Antibody responses against SARS-CoV-2 have been given a lot of attention. However, the armamentarium of humoral and T cells may have differing roles in different viral infections. Though the exact role of T cells in COVID-19 remains to be elucidated, prior experience with human coronavirus has revealed an essential role of T cells in the outcomes of viral infections. Moreover, an increasing body of evidence suggests that T cells might be effective against SARS-CoV-2. This review summarizes the role of T cells in mouse CoV, human pathogenic respiratory CoV in general and SARSCoV- 2 in specific. |