| Title | The crosstalk between bacteria and host autophagy: host defense or bacteria offense |
|---|---|
| Author | Lin Zheng1, Fang Wei1*, and Guolin Li2* |
| Address | 1Center for Biomedical Aging, National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P. R. China, 2Key Laboratory of Hunan Province for Model Animal and Stem Cell Biology, School of Medicine, Hunan Normal University, Changsha, Human 410081, P. R. China |
| Bibliography | Journal of Microbiology, 60(5),451–460, 2022, |
| DOI | 10.1007/s12275-022-2009-z |
| Key Words | autophagy, xenophagy, bacteria, infection, bacterial effector |
| Abstract | Xenophagy is a specific selective autophagy for the elimination of intracellular bacteria. Current evidence suggests that the processes for host autophagy system to recognize and eliminate invading bacteria are complex, and vary according to different pathogens. Although both ubiquitin-dependent and ubiquitin-independent autophagy exist in host to defense invading bacteria, successful pathogens have evolved diverse strategies to escape from or paralyze host autophagy system. In this review, we discuss the mechanisms of host autophagy system to recognize and eliminate intracellular pathogens and the mechanisms of different pathogens to escape from or paralyze host autophagy system, with a particular focus on the most extensively studied bacteria. |