Title |
Host–microbial interactions in metabolic diseases: from diet to immunity |
Author |
Ju-Hyung Lee and Joo-Hong Park* |
Address |
School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 08826, Republic of Korea |
Bibliography |
Journal of Microbiology, 60(6),561-575, 2022,
|
DOI |
10.1007/s12275-022-2087-y
|
Key Words |
microbiome, obesity, metabolic disease, lipid, inflammation |
Abstract |
Growing evidence suggests that the gut microbiome is an important
contributor to metabolic diseases. Alterations in microbial
communities are associated with changes in lipid metabolism,
glucose homeostasis, intestinal barrier functions,
and chronic inflammation, all of which can lead to metabolic
disorders. Therefore, the gut microbiome may represent a
novel therapeutic target for obesity, type 2 diabetes, and nonalcoholic
fatty liver disease. This review discusses how gut microbes
and their products affect metabolic diseases and outlines
potential treatment approaches via manipulation of the
gut microbiome. Increasing our understanding of the interactions
between the gut microbiome and host metabolism
may help restore the healthy symbiotic relationship between
them. |