| Title | Rhizopus nigricans에 의한 progesterone 전환 반응의 경로 | ||
| Author | 김명희 · 김말남 | ||
| Address | 상명여자대학교 자연과학대학 생물학과 | ||
| Bibliography | Korean Journal of Microbiology, 29(2),111-116, 1991 | ||
| DOI | |||
| Key Words | Rhizopus nigricans, progesterone, 11α-hydrozyprogesterone, 11α-hydroxy-allopregnane-3,20-dione, 6β, 11 α-dihydroxyprogesterone | ||
| Abstract | Rhizopus nigricans produces 11α-hydroxyprogesternoe with a unidentified byproduct, which is hardly separated. Results of chromatography, IR and NMR spectroscopy identified the byproduct to be 11α-hydroxy-allopregnane-3,20-dione. R. nigricans was found to transform progesternoe into a monoform intermediate, 11α-hydroxyprogesterone, from which 11α-hydroxy-allopregnane-3,20-dione and 6β, 11α - dihydroxyprogesterone were formed respectively by 5α-reduction and 6β-hydroxylation. | ||
| Download PDF | Kor_290207_111-116p.pdf | ||