| Title | B형 간염바이러스 표면단백질 중 preS2 부위의 항원적 특성 | ||
| Author | 이기녕 · 이상철 · 권기선 · 정홍근 * · 유명희 § | ||
| Address | §한국과학기술연구원 유전공학센타; * 서울대학교 의과대학 생화학과 | ||
| Bibliography | Korean Journal of Microbiology, 28(1),6-12, 1990 | ||
| DOI | |||
| Key Words | preS2, monoclonal antibody, β-galactosidase-preS2 fusion | ||
| Abstract | The preS2 wequence of an adr hepatitis B virus was cloned and expressed in Escherichia coli as a β-galactosidase fusion polypeptide. Recombinant preS2 product interacted with the preS2-specific monoclonal antibody H8 which was induced by surface antigen particles isolated from a Korean gepatitis patient. The H8 showed only a minor cross-reactivity with recombinant preS2 product of adw2 subtype. Determination of nucleotide sequence of the adr preS2 revealed that twelve amino acid residue substitutions between adr and adw2 subtype sequences. The antigenic determinant to H8 must include some of these differences. | ||
| Download PDF | Kor_280102_6-12p.pdf | ||