| Title | Staphylococcus aureus DH1에서 분리된 macrolide-lincosamide-streptogramin B 계열 항생물질에 대한 저항성 인자의 특성과 염기서열 | ||
| Author | 권동현 · 박승문 · 윤권상 · 변우현 | ||
| Address | 강원대학교 자연과학대학 미생물학과 | ||
| Bibliography | Korean Journal of Microbiology, 28(1),27-34, 1990 | ||
| DOI | |||
| Key Words | Staphylococcus aureus, r-plasmid, KLS resistance, erm | ||
| Abstract | Two macrolide-lincosamide-streptogramin B (MLS) antibiotic resistance genes, one expressed inducibly and the other expressed constitutively were recognized from a single Staphylococcus aureus DH1 strain. The inducible MLS resistance gene was isolated and cloned from the R-plasmid pDE1(7.4kb) and the constitutive gene was from chromosomal DNA. Base sequence of the inducible MLS resistance gene (1.2kb) was determined and found as same that of pE194. The restriction map of the cloned constitutive MLS resistance gene was compared with that of the inducible gene. Two genes have same restriction map except leader region. In the constitutive gene there is no leader region which is doing major role in inducible expression. | ||
| Download PDF | Kor_280105_27-34p.pdf | ||