| Title | 항결핵제, 리팜피신에 내성인 유산균 lactobacillus sporogenes의 개발 | ||
| Author | 김희선 · 최성숙 · 최응칠 · 김병각 · 이정치 * · 김태한 * | ||
| Address | 서울대학교 약학대학; * 일동제약(주) 중앙연구소 | ||
| Bibliography | Korean Journal of Microbiology, 27(2),155-161, 1989 | ||
| DOI | |||
| Key Words | Lactobacillus sporogenes, rifampicin resistant mutant, N-methyl-N'-nitro-N-nitrosoguanidine(NTG) | ||
| Abstract | Lactobacillus sporogenes was treated with N-methyl-N'-nitro-N-nitrosoguanidine (NTG) to obtain resistant mutants to rifampicin. Fifty-eight strains of the NTG-induced mutants showed distinct resistance to rifampicin and nine mutants were selected for further studies. They also exhibited identical characteristics with the parent Lactobacillus sporogenes when they were tested for spore formation, acid formation and growth inhibition of E. coli. From in vitro test it was identified that rifampicin is not inactivated by certain factors of the rifampicin resistant mutants. It is suggested that they can be utilized as efficient normalizing agents for human intestinal flora when they are simultaneously taken with rifampicin | ||
| Download PDF | Kor_2702011_155-161p.pdf | ||