| Title | 돼지 태아 신장세포에 있어 parvovirus KBSH의 DNA 복제과정에 관하여 | ||
| Author | 이성욱 · 김연수 · 강현삼 | ||
| Address | 서울대학교 자연과학대학 미생물학과 | ||
| Bibliography | Korean Journal of Microbiology, 25(1),34-39, 1987 | ||
| DOI | |||
| Key Words | parvovirus KBSH, embryonic swine kidney cells, viral hemagglutinating antigen, viral double-stranded replicative form DNA | ||
| Abstract | To study the replication process of the single-stranded DNA parvovirus KBSH-isolated from normal human cell cultures-in actively dividing embryonic swine kidney cells, amount of the synthesized viral hemagglutination (HA) antigen and the overall rate of viral double-stranded replicative form(RF) DNA synthesis were examined. The initiation of viral RF KNA synthesis and the decrease of host DNA synthesis rate in viral infected cells occurred almost same time at 15-16 hour post infection(PI). And the release of viral HA antigen to media followed at 24 hour PI, concurrently the overall rate of viral RF DNA synthesis reaching its maximum. Evidence is presented which indicates that successful performance of viral RF DNA replication requires proteins synthesized in viral infected cells at 10-14 hour PI. | ||
| Download PDF | Kor_250106_34-39p.pdf | ||