| Title | 페니실린 발효 공정에 있어서 탄소원 및 다른 공정변수가 미치는 영향 | ||
| Author | 이진선 · 신규철 · 양호석 · 유두영 * | ||
| Address | 주식회사 종근당; * 한국과학원 | ||
| Bibliography | Korean Journal of Microbiology, 16(1),21-29, 1978 | ||
| DOI | |||
| Key Words | Effects of carbon sources and other process variables in fed-batch fermentation of penicillin | ||
| Abstract | In the fed-batch fermentation of penicillin specific uptake rates of carbon source and ammonia nitrogen, and specific production rate of penicillin as the most important process variables were evaluated over the fermentation course and their effects on the productivity studied. As the results, glucose and lactose each as a major carbon source showed the following values, respectively ; the specific uptake rates of 47-93 mg hexose per gm-DCW per he and 37-44 mg hexose per gm-DCW per hr, the specific uptake rates of 4.6-6.8 mg NH₃-N per gm-DCW per hr, and 1.2 mg NH₃-N per gm-DCW per he and the specific production rates of 32-42 arbitrary unit per gm-DCW per hr and 46-50 arbitrary unit per gm-DCW per hr. The productivity of penicillin could be improved by controlling the feed rates of glucose and ammonia nitrogen to meet the uptake rates. | ||
| Download PDF | Kor_160104_21-29p.pdf | ||