Title 전이방사선을 이용한 의료제품 멸균연구 III
Author 이강순 · 천기정 · 김기수
Address 한국원자력연구소 방사선생물학연구실
Bibliography Korean Journal of Microbiology, 15(4),154-158, 1977
DOI
Key Words Radiosterilization of Medical Priducts (III); Effect of Gamma Irradiation (^60Co) on Activity of Antibiotics
Abstract Fifteen kinds of antibiotics both in liquid or dry states were investigated for the purpose of radiation effect on the antibiotic activities after irradiation. In liquid states, the antibiotics such as amoxyllin, ampicillin, capharolidin and hetacillin were inctivated 90% of their antibiotic activities at radiation doses of 50Krad, and penicillin, dicloxacillin, caphalothin, cloxacillin, erythromycin and caphalexin and kanamycin were decomposed at radiation doses of 1.5Mrad, respectively. In dry states, all antibiotics were stable at radiation doses of 5Mrad. On the other hand, the neomycin in liquid state was rather increased the antiboctic activity about 1.2 and 8 times when the E. coli ATCC 113-3 and B. subtitilis ATCC 6633 were used as a standard microorganisms, whereas, the decreased antibiotic activities were observed in S. typhi Ty-2(36.2%), St.faecium(10.79%), B.sphaericus CIA(9.066%) and St.aureus ATCC 6538p(70%).
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