It seems like that the characteristics and drug-resistances of fungi are respectively different in various circumstances. Scores of chemicals were applicated to the leather-fungi in this study. M-dinitrobenzene, 2, 4-dinitrochlorobenzene and phenyl mercuric acetate inhibited the growth of Aspergilli which were isolated from Korean-leather. The minimum fungicidal limits of p-nitrophenol, 8-hydroxyquinoline and sodium-pentachlorophenolate against the Korean-originated strains are different from that of other country. In the mass-screening of fungicides, artificial "Leather-extracts media" have been designed and used, and the media contributed to screening-tests. Fat and oils which are the materials of fat-liquoring in leather manufacture affects the drugresistance of the leather-fungi. It is found that the accelerating-method on malt-agar plate is effective to determinate the fungicidal action of chemicals in short time.