Title |
Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity |
Author |
Dokyung Lee1, Jaeeun Park1, Minji Kim1, Youngjoo Lee1, Jaegoo Seo2, Namjoo Ha1, and Kyungjae Kim1* |
Address |
1College of Pharmacy, Sahmyook University, Seoul 139-742, Republic of Korea, 2R&D Center, Cellbiotech Co. Ltd., Kimpo 157-030, Republic of Korea |
Bibliography |
Korean Journal of Microbiology, 51(3),280-287, 2015 |
DOI |
http://dx.doi.org/10.7845/kjm.2015.5031
|
Key Words |
Bifidobacterium adolescentis, carbon tetrachloride, hepatoprotective effect, probiotics |
Abstract |
Probiotics are microbial food supplements or components of bacteria which have traditionally been added to dairy foods for extra
health boost. Our aim was to evaluate the hepatoprotective effect of Bifidobacterium adolescentis SPM0212 as probiotics, which we previously
found has potential anti-hepatitis B virus activity. The study was conducted using Wistar albino rats and probiotics were treated orally for 9 days
consecutively and acute liver injury was induced by administration of carbon tetrachloride (CCl4) on the 7th and 8th days. Liver damage was
assessed by quantifying serum activities of glutamate oxaloacetate transaminase (SGOT) and glutamate pyruvate transaminase (SGPT), as well
as by histopathological examination. B. adolescentis SPM0212 significantly prevented the elevation of SGOT and SGPT levels, and reduced the
negative effect of CCl4 on body and organ weights. Histopathological study revealed the livers of the carbon tetrachloride treated rats showed
almost complete loss of normal hepatocyte architecture, but that rats treated with B. adolescentis SPM0212 showed minimal damage and
normal hepatocyte architecture. Our results suggest that B. adolescentis SPM0212 be considered useful probiotics for protecting the liver
from xenobiotics and hepatitis B virus, and as well as useful as a functional food for maintaining human health. |
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51(3)_12_p.280-287.pdf |