| Title | Anti-multi drug resistant pathogen activity of siderochelin A, produced by a novel Amycolatopsis sp. KCTC 29142 | ||
| Author | Dong-Ryung Lee1, Jinhua Cheng1,2, Sung-Kwon Lee1, Hee-Jeon Hong3, Jaekyeong Song4, Seung Hwan Yang5*, and Joo-Won Suh1,2* | ||
| Address | 1Center for Nutraceutical and Pharmaceutical Materials Myongji University, Yongin 17058, Republic of Korea, 2Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University, Yongin 17058, Republic of Korea, 3Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom, 4Division of Agricultural Microbiology, National Academy of Agricultural Science, Rural Development Administration, Jeonju 56050, Republic of Korea, 5Department of Biotechnology, Chonnam National University, Gwangju 59626, Republic of Korea | ||
| Bibliography | Korean Journal of Microbiology, 52(3),327-335, 2016 | ||
| DOI | http://dx.doi.org/10.7845/kjm.2016.6033 | ||
| Key Words | Amycolatopsis, antibacterial activity, anti-multi drug resistant pathogens, Siderochelin A | ||
| Abstract | A novel Amycolatopsis strain KCTC 29142 was isolated and characterized based on the polyphasic taxonomic analysis including morphological observation, phylogenetic analysis, physiological and chemotaxonomic characteristics. The ethyl acetate extract of strain KCTC 29142 culture broth showed strong antibacterial activity and the active compound was identified as siderochelin A, a ferrous-ion chelating compound. In this study, siderochelin A showed good activity against multi-drug resistant pathogens, including Acinetobacter baumanii, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), and Escherichia coli (E. coli ). The minimum inhibitory activity against clinical isolates was also determined. | ||
| Download PDF | 52(3)_12_p.327-335.pdf | ||