| Title | 단보] Anti-tumor effect of Inonotus obliquus in xenograft animals with EBV+human gastric carcinoma | ||
| Author | Seulki Lee and Hyosun Cho* | ||
| Address | College of Pharmacy, Duksung Women’s University, Seoul 01369, Republic of Korea | ||
| Bibliography | Korean Journal of Microbiology, 52(4),482-486, 2016 | ||
| DOI | https://doi.org/10.7845/kjm.2016.6054 | ||
| Key Words | Inonotus obliquus, EBV+human gastric carcinoma, caspase-9, p53, PARP | ||
| Abstract | Inonotus obliquus is a medicinal mushroom with a variety of biological activities. It has reported to have strong anti-cancer, antioxidant and anti-inflammatory properties. EBV+ gastric carcinoma is one of the most common EBV-associated cancers that were caused by latent EBV infection. In this study, we investigated the anti-cancer effects of ethanol extract of I. obliquus using in vivo xenograft animal models implanted with EBV+ human gastric carcinoma (SNU719). We also explored the molecular mechanisms responsible for its anti-cancer activity. The result indicated that the extract of I. obliquus had an anti-cancer effect in in vivo xenograft mice with EBV+ gastric carcinoma (SNU719). Extract of I. obliquus also showed a great effect on inducing the expression of p53, p21 and Bax in tumor tissue derived from EBV+ human gastric carcinoma, and these were correlated with increased expressions of the cleaved forms of caspase-9 and Parp. Also, I. obliquus attenuated the expression of viral proteins, BZLF-1 and LMP-2 in tumor tissue from EBV+ human gastric carcinoma. | ||
| Download PDF | 52(4)_12_482-486.pdf | ||